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Naltrexone for Opioid Addiction

What is Naltrexone?

NaltrexoneNaltrexone is commonly prescribed to treat opioid addictions. By blocking the harmful effects of opioids, the medication reduces the cravings usually caused by the drugs. It should be used as part of a comprehensive recovery program that may consist of counseling, support groups and other treatment methods recommended by your doctor or addiction treatment specialist.

"Naltrexone blocks the negative effects opioids have on the brain and prevents the feeling of getting high."

Naltrexone will trigger withdrawal symptoms if you are currently physically dependent on opioids. It’s important to refrain from taking opioids for a minimum of 7-10 days before taking naltrexone to reduce the risk of a withdrawal. However, the length of time will vary from one person to another depending on the type of opioid addiction, the dose and how long the addiction lasted.

Recovering from an addiction to opioids takes time and patience, as it’s not a quick process. But with the help of medications like naltrexone and an array of treatment options available, you will have support every step of the way. Connect with us today and find a treatment center near you.

Uses of Naltrexone

Naltrexone works differently than other types of medication used in opioid addiction treatment. Medicines like buprenorphine and methadone help reduce cravings. On the other hand, naltrexone eliminates any desire to take opioids. By blocking these opioid receptors, naltrexone users do not experience the euphoric and sedative effects of taking opioids.

"Naltrexone does not cause any withdrawals or cravings when you stop taking it."

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How Does Naltrexone Help Addiction Treatment?

Oftentimes, opioids will give you a “high” or “rush” feeling – a feeling of contentment and pain relief. When taking naltrexone, these feelings will be blocked. Over time, you will regain a drug-free state of mind, allowing you to focus on developing a healthier lifestyle.

Although naltrexone is commonly used to treat an opioid addiction, it may not stop drug cravings. For this reason, naltrexone is usually best suited for those who have completed the withdrawal stage and are motivated to continue on in the recovery process. Alert your doctor or addiction treatment specialist immediately if you experience any cravings for opioids.

You may be more sensitive to lower doses of opioids after taking naltrexone, so you should abstain from taking any drugs at the conclusion of your medication-assisted treatment. Falling back on heroin or any other opioids could cause serious complications, including an overdose.

How is Naltrexone Administered?

Naltrexone is available in three forms: tablet, injectable and implant device. Common brand names for the tablet are ReVia and Depade. The injectable extended-release form of the drug is often sold under the name Vivitrol.

"Naltrexone is most commonly administered in a tablet form; however, the injectable and implant device options are gaining momentum."

Tablet-form doses of naltrexone will vary by person, strength of the medicine and the amount of medicine required each day. Follow your doctor’s instructions for consumption information. It can be taken at home or in a treatment center setting. If you’re taking the tablet form at home, it may be helpful to have a family member or caregiver administer the doses as scheduled. Do not adjust your amount of medication unless your doctor tells you to.

Another form of naltrexone is a type of implant used for treatment. Implants are shaped like small pellets and are inserted into the lower abdominal wall. Insertion is completed with a local anesthetic. Once implanted, the device releases a consistent amount of naltrexone in the body for approximately 3-6 months. Currently, implants are only available in an inpatient treatment setting in order to monitor potential side effects.

The medication can also be administered through an extended-release injectable. Each month, the medication is injected into a muscle. It can only be administered by a doctor or nurse in a clinic setting, so it’s important to receive doses regularly in order to achieve the greatest benefit. Shortly after receiving the medication, you may notice pain, redness, bruising or swelling near the injection site. While this is common, be sure to notify your doctor if it does not go away or gets worse within two weeks.

Side Effects of Naltrexone

Taking naltrexone may cause side effects. These generally disappear once your body adjusts to the medicine. Minor side effects that have been reported include:

  • Headache
  • Nausea
  • Tiredness
  • Mild abdominal pain
  • Trouble sleeping
  • Joint or muscle pain

Always talk with your healthcare provider or addiction treatment specialist about potential side effects and complications before starting naltrexone. This will give you an opportunity to clarify any questions or concerns you may have prior to taking the medication.

Naltrexone Interactions

Sometimes, naltrexone can cause unpleasant effects when combined with certain medications, including ones that are over-the-counter, prescribed, supplements or herbal remedies. Several of the more common drugs that may counteract with naltrexone are:

  • Opioids
  • Methadone
  • Certain medications for diarrhea, cough and pain
  • Disulfiram
  • Thioridazine

Keep an updated list of all medications you are currently taking and speak with your doctor about drug interactions before taking naltrexone. Check with your doctor immediately if you begin to experience any negative side effects from taking the medication.

Where is Naltrexone Available?

Naltrexone is only available with a doctor’s prescription. Your doctor or addiction treatment specialist will work with you to develop a recovery plan tailored to your needs. Depending on where you are in treatment, the medication may be administered in an inpatient facility or at your home. Medication-assisted therapy, such as the use of naltrexone, should always be used as part of an overall recovery program to achieve long-term sobriety.

If your or someone you love is struggling with an opioid addiction, medications like naltrexone may be able to help. Get in touch with us today to find a treatment center.

Naltrexone Statistics



When naltrexone is prescribed, patients have an 80 percent cure rate for alcohol dependence.




Medications, opioid agonist, partial agonist and antagonist, significantly increase the success of treatment and reduce overdoses by at least 30 to 50 percent.




Nearly three-quarters of opioid users also regularly drink alcohol. Research indicates that taking naltrexone may address both issues simultaneously.


The Time for Help Is Now

Do you want to find out if naltrexone can play or role in the treatment of your or a loved one’s addiction? Do you have any other questions about your addiction recovery options? A full staff of dedicated treatment professionals is waiting to answer them. Contact us now to start taking your life back.

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